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The tectonic complex regulates membrane protein composition in the photoreceptor cilium
Truong HM, Cruz-Colón KO, Martínez-Márquez JY, Willer JR, Travis AM, Biswas SK, Lo WK, Bolz HJ, Pearring JN
Nature Communications. 2023; 14(1):5671. PMID:37704658
Nrl:CreERT2 mouse model to induce mosaic expression in rod photoreceptors
Thorson MT, Wei SE, Johnson C, Gabriel CJ, Arshavsky VY, Pearring JN
Frontiers in Molecular Neuroscience. 2023; 16:1161127. PMID: 37181654
CEP162 deficiency causes human retinal degeneration and reveals a dual role in ciliogenesis and neurogenesis
Nuzhat N, Van SchilK, Liakopoulos S, Bauwens M, Rey AD, Käseberg S, Jäger M, Willer JR, Winter J, Truong HM, Gruartmoner N, Van Heetvelde M, Wolf J, Merget R, Grasshoff-Derr S, Van Dorpe J, Hoorens A, Stöhr H, Mansard L, Roux AF, Langmann T, Dannhausen K, Rosenkranz D, Wissing KM, Van Lint M, Rossmann H, Häuser F, Nürnberg P, Thiele H, Zechner U, Pearring JN*, De Baere E*, Bolz HJ*
Journal of Clinical Investigation. 2023; 133(8):e161156. PMID: 36862503
Mechanistic Analysis of CCP1 in Generating ΔC2 α-Tubulin in Mammalian Cells and Photoreceptor Neurons
Hotta T, PlemmonsA, Gebbie M, Ziehm TA, Blasius TL, Johnson C, Verhey KJ, Pearring JN, Ohi R
Biomolecules. 2023; 13(2):357. PMID: 36830726
Disrupting the ciliary gradient of active Arl3 affects rod photoreceptor nuclear migration
Travis AM, Manocha S, Willer JR, Wessler TS, Skiba NP, Pearring JN
eLife. 2023; 12:e80533. PMID: 36598133
The GARP Domain of the rod CNG channel's β1-subunit contains distinct sites for outer segment targeting and connecting to the photoreceptor disk rim
Pearring JN, Martínez-Márquez J, Willer JR, Lieu EC, Salinas RY, Arshavsky VY.
Journal of Neuroscience. 2021; 41(14):3094-3104. PMID:33637563
This image shows photoreceptor neurons in a mouse retina. A subset of rod photoreceptors are labeled with mCherry (red) and are expressing the alpha (magenta) and beta (green) subunits of the rod cyclic nucleotide-gated (CNG) channel. In the article by Pearring et al, the authors identify distinct sites encoded within the beta subunit that are used to specifically target the CNG channel to the light-sensitive outer segment compartment and subsequently sequester the CNG channel into the plasma membrane surrounding the membrane discs.
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