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Photoreceptor discs form through peripherin-dependent suppression of ciliary ectosome release.

Salinas RY*, Pearring JN*, Ding JD*, Spencer WJ, Hao Y, Arshavsky VY.

Journal of cell biology. 2017; 216(5):1489-1499.


Loss of Arf4 causes severe degeneration of the exocrine pancreas but not cystic kidney disease or retinal degeneration.

Pearring JN, San Agustin JT, Lobanova ES, Gabriel CJ, Lieu EC, Monis WJ, Stuck MW, Strittmatter L, Jaber SM, Arshavsky VY, Pazour GJ.

PLoS genetics. 2017; 13(4):e1006740.


Dimerization deficiency of enigmatic retinitis pigmentosa-linked rhodopsin mutants.

Ploier B, Caro LN, Morizumi T, Pandey K, Pearring JN, Goren MA, Finnemann SC, Graumann J, Arshavsky VY, Dittman JS, Ernst OP, Menon AK.

Nature communications. 2016; 7:12832.



De Novo GMNN Mutations Cause Autosomal-Dominant Primordial Dwarfism Associated with Meier-Gorlin Syndrome.

Burrage LC, Charng WL, Eldomery MK, Willer JR, Davis EE, Lugtenberg D, Zhu W, Leduc MS, Akdemir ZC, Azamian M, Zapata G, Hernandez PP, Schoots J, de Munnik SA, Roepman R, Pearring JN, Jhangiani S, Katsanis N, Vissers LE, Brunner HG, Beaudet AL, Rosenfeld JA, Muzny DM, Gibbs RA, Eng CM, Xia F, Lalani SR, Lupski JR, Bongers EM, Yang Y.

American journal of human genetics. 2015; 97(6):904-13.


Guanylate cyclase 1 relies on rhodopsin for intracellular stability and ciliary trafficking.

Pearring JN, Spencer WJ, Lieu EC, Arshavsky VY.

eLife. 2015; e12058.


R9AP targeting to rod outer segments is independent of rhodopsin and is guided by the SNARE homology domain

Pearring JN, Lieu EC, Winter JR, Baker SA, Arshavsky VY.

Molecular biology of the cell. 2014; 25(17):2644-9.


Protein sorting, targeting and trafficking in photoreceptor cells.

Pearring JN, Salinas RY, Baker SA, Arshavsky VY.

Progress in retinal and eye research. 2013; 36:24-51. 


Depolarizing bipolar cell dysfunction due to a Trpm1 point mutation.

Peachey NS, Pearring JN, Bojang P Jr, Hirschtritt ME, Sturgill-Short G, Ray TA, Furukawa T, Koike C, Goldberg AF, Shen Y, McCall MA, Nawy S, Nishina PM, Gregg RG.

Journal of neurophysiology. 2012; 108(9):2442-51.


GPR179 is required for depolarizing bipolar cell function and is mutated in autosomal-recessive complete congenital stationary night blindness.

Peachey NS, Ray TA, Florijn R, Rowe LB, Sjoerdsma T, Contreras-Alcantara S, Baba K, Tosini G, Pozdeyev N, Iuvone PM, Bojang P Jr, Pearring JN, Simonsz HJ, van Genderen M, Birch DG, Traboulsi EI, Dorfman A, Lopez I, Ren H, Goldberg AF, Nishina PM, Lachapelle P, McCall MA, Koenekoop RK, Bergen AA, Kamermans M, Gregg RG.

American journal of human genetics. 2012; 90(2):331-9.


A role for nyctalopin, a small leucine-rich repeat protein, in localizing the TRP melastatin 1 channel to retinal depolarizing bipolar cell dendrites.

Pearring JN, Bojang P Jr, Shen Y, Koike C, Furukawa T, Nawy S, Gregg RG.

Journal of neuroscience. 2011; 31(27):10060-6. 


Mutations in TRPM1 are a common cause of complete congenital stationary night blindness.

van Genderen MM, Bijveld MM, Claassen YB, Florijn RJ, Pearring JN, Meire FM, McCall MA, Riemslag FC, Gregg RG, Bergen AA, Kamermans M.

American journal of human genetics. 2009; 85(5):730-6.

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